Vitamin B12 deficiency can cause anemia and also peripheral neuropathy (nerve damage in the feet, legs, hands, and arms).Īnother type of diabetes drug, the thiazolidinediones, which include pioglitazone (Actos) and rosiglitazone (Avandia), can also cause mild anemia by slightly decreasing hemoglobin levels and hematocrit, a measurement of the proportion of blood that is made up of red blood cells. It is now recognized that metformin can cause malabsorption of vitamin B12 and that long-term use (12–15 years) of metformin leads to vitamin B12 deficiency in 30% of people who use it. Metformin is the most widely prescribed treatment for people with Type 2 diabetes. About 20% of people with heart failure are anemic.ĭiabetes drugs. Decreased heart function can cause kidney dysfunction, and many people with heart failure also have nutritional deficiencies both of these can contribute to anemia. People who have diabetes are at increased risk for heart failure, or the inability of the heart to pump adequate blood to meet the body’s needs. In people who have a type of neuropathy called autonomic neuropathy, the body may not be able to properly signal the kidneys to produce more erythropoietin in response to anemia. Some studies have shown that reduced erythropoietin production and anemia happen earlier in people with diabetes and kidney disease than in those with kidney disease and no diabetes.īoth chronically high blood glucose levels and high blood pressure can cause kidney damage.
At the same time, the amount of erythropoietin produced by the kidneys is reduced, leading to anemia. In diabetic nephropathy, the tiny blood vessels that filter waste products from the body become damaged and start “leaking” substances (such as protein) into the urine.
Normally, the kidneys secrete a hormone called erythropoietin, which stimulates the bone marrow to produce red blood cells. People with diabetes can also have anemia as a result of not eating well or of having a condition that interferes with the absorption of nutrients. In addition, taking certain oral diabetes drugs can raise the risk of developing anemia.
For example, both diabetes-related kidney disease ( nephropathy) and nerve damage ( neuropathy) can contribute to the development of anemia. Diabetes and anemiaĭiabetes does not directly cause anemia, but certain complications and conditions associated with diabetes can contribute to it. But even mild anemia can significantly lower one’s quality of life, and untreated anemia can have serious long-term health effects. Its symptoms are vague and easily mistaken for symptoms of other serious or chronic diseases. Anemia caused by red blood cell destructionĪnemia is a fairly common condition, but it often goes unrecognized and therefore not treated.Anemia caused by a decrease in red blood cell production in the bone marrow or impaired production of red blood cells.But they can all be categorized into these three general groups: In fact, there are more than 400 types of anemia. A low oxygen level can cause fatigue and other symptoms such as weakness, difficulty exercising, and light-headedness.Īnemia can develop for many reasons. When either the number of red blood cells or the amount of hemoglobin is low, the body’s cells receive less oxygen than normal. Red blood cells also carry waste products from the cells to the urinary and respiratory systems to be excreted. The specific part of the red blood cell that carries oxygen is called hemoglobin. Red blood cells carry oxygen from your lungs to the rest of your body.
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